Double-stranded RNA (dsRNA) is a major impurity of therapeutic mRNA produced by in vitro transcription. Impurity levels of this transcriptional by-product need to be tightly monitored in mRNA production lots to ensure efficient mRNA expression and to reduce the risk of undesired high immunogenicity.

Hot Start technology developed by Jena Bioscience increases specificity and reduces false-positives. Our Hot Start Taq polymerases are inactivated at room temperature, preventing nonspecific amplification products and primer-dimers.

Nucleases (e.g. DNases & RNases) are enzymes facilitating the cleavage of phosphodiester bonds in nucleic acids (RNA, ss- or ds-DNA). Due to their omnipresence in the environment, they are a constant contamination risk especially to molecular biological applications such as PCR reactions.

We welcome Everon Life Sciences as a new distributor of Jena Bioscience's products in India! Find all contact information here.